Izumi, Masayuki published the artcileMannose-BSA Conjugates: Comparison Between Commercially Available Linkers in Reactivity and Bioactivity, Formula: C18H20N2O12, the publication is Journal of Carbohydrate Chemistry (2003), 22(5), 317-329, database is CAplus.
Mannosyl ethanolamine and BSA were conjugated together by their amino groups with various homobifunctional cross-linker reagents: disuccinimidyl carbonate (DSC), disuccinimidyl glutarate (DSG), disuccinimidyl suberate (DSS), ethylene glycolbis(succinimidyl-succinate) (EGS), 1,5-difluoro-2,4-dinitrobenzene (DFDNB), di-Et squarate (DES), and thiophosgene (TP). The resulting mannose-BSA conjugates were subjected to an enzyme-linked lectin assay (ELLA)to investigate their affinity to Con A (ConA). With these results, the seven linkers were evaluated on the basis of five criteria, i.e., cost, reactivity, sugar loading, homogeneity, and affinity to ConA. Thus, DSS, DFDNB, and DES seemed to have advantages over the other crosslinking reagents.
Journal of Carbohydrate Chemistry published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Formula: C18H20N2O12.
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