Hu, Peipei published the artcileAssociations between exposure to a mixture of phenols, parabens, and phthalates and sex steroid hormones in children 6-19 years from NHANES, 2013-2016, COA of Formula: C12H10O4S, the publication is Science of the Total Environment (2022), 153548, database is CAplus and MEDLINE.
Humans are typically exposed to mixtures of environmental endocrine-disrupting chems. simultaneously, but most studies have considered only a single chem. or a class of similar chems. We examined the association of exposure to mixtures of 7 chems., including 2 phenols [bisphenol A (BPA) and bisphenol S (BPS)], 2 parabens [methylparaben (MeP) and Pr paraben (PrP)], and 3 phthalate metabolites [Mono-benzyl phthalate (MBzP), mono-iso-Bu phthalate (MiBP), mono (carboxyoctyl) phthalate (MCOP)] with sex steroid hormones. A total of 1179 children aged 6-19 years who had complete data on both 7 chems. and sex steroid hormones of estradiol (E2), total testosterone (TT), and sex hormone-binding globulin (SHBG) were analyzed from the U. S. National Health and Nutrition Examination Survey 2013-2016. Free androgen index (FAI) calculated by TT/SHBG, and the ratio of TT to E2 (TT/E2) were also estimated Puberty was defined if TT ≥ 50 ng/dL in boys, E2 ≥ 20 pg/mL in girls; otherwise prepuberty was defined. Linear regression, weighted quantile sum (WQS) regression, and Bayesian kernel machine regression (BKMR) were performed to estimate the associations of individual chem. or chem. mixtures with sex hormones. The linear regression showed that 2 phenols, 2 parabens, and 3 phthalate metabolites were generally neg. associated with E2, TT, FAI, and TT/E2, while pos. with SHBG. Moreover, these associations were more pronounced among pubertal than prepubertal children. The aforementioned associations were confirmed when further applying WQS and BKMR, and the 3 phthalates metabolites were identified to be the most heavily weighing chems. Exposure to phenols, parabens, and phthalates, either individuals or as a mixture, was neg. associated with E2, TT, FAI and TT/E2, while pos. with SHBG. Those associations were stronger among pubertal children.
Science of the Total Environment published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, COA of Formula: C12H10O4S.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
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