Alexis, Michael N.’s team published research in European Journal of Biochemistry in 204 | CAS: 70539-42-3

European Journal of Biochemistry published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Related Products of alcohols-buliding-blocks.

Alexis, Michael N. published the artcileSubunit composition of the untransformed glucocorticoid receptor in the cytosol and in the cell, Related Products of alcohols-buliding-blocks, the publication is European Journal of Biochemistry (1992), 204(1), 75-84, database is CAplus and MEDLINE.

Bifunctional reagents were used to exam. the subunit composition of the non-DNA-binding form of the rat and human glucocorticoid receptor. Treatment of intact cells and cell extracts with a reversible cross-linker, followed by electrophoretic anal. of immunoadsorbed receptor revealed that 3 proteins of apparent approx. mol. masses, 90, 53, and 14 kDa are associated with the receptor. The 1st of these was identified immunochem. as a 90-kDa heat-shock protein (hsp90). The complex isolated from HeLa cells contained 2.2 mol hsp90/mol steroid-binding subunit. Crosslinking of the receptor complex in the cytosol completely prevented salt-induced dissociation of the subunits. The cross-linked receptor was electrophoretically resolved into 2 oligomeric complexes of apparent mol. mass 288 kDa and 347 kDa, reflecting the association of the 53-kDa protein with a fraction of the receptor. Since no higher oligomeric complexes could be generated by crosslinking cell extracts under different conditions, it was concluded that most of the untransformed cytosolic receptor is devoid of addnl. components.

European Journal of Biochemistry published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts