Zhang, Da-Wei published the artcileEfficient synthesis of bis-isoxazole ethers via 1,3-dipolar cycloaddition catalysed by Zn/Zn2+ and their antifungal activities, Computed Properties of 438565-33-4, the publication is Chemical Papers (2015), 69(11), 1500-1511, database is CAplus.
A series of novel bis-isoxazole ether compounds I [R = 3-pyridyl, 3-O2NC6H4, 4-O2NC6H4, 4-(H3C)3CC6H4; R1 = 4-C(CH3)3, 3-NO2, (Z)-CH=CHC6H5, etc.] were synthesized starting from different substituted aldehydes RCHO and R1CHO via 1,3-dipolar cycloaddition using Zn/Zn2+ as a catalyst. In addition, the antimicrobial properties of synthesized products were investigated. The synthesized compounds I exhibited significant antifungal activities in comparison with the standard drugs, fluconazole and itraconazole. It was found that Candida albicans was sensitive to 2-substituted Ph bis-isoxazole ethers bearing pyridyl I [R1 = 2-OCH3, 2-Cl].
Chemical Papers published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C12H17NS2, Computed Properties of 438565-33-4.
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