Yong, Jianping published the artcileSynthesis of Isoxazole Moiety Containing Thieno[2,3-d]pyrimidine Derivatives and Preliminarily in vitro Anticancer Activity (Part II), Name: 3-(2-Chlorophenyl)-5-isoxazolemethanol, the publication is Anti-Cancer Agents in Medicinal Chemistry (2015), 15(9), 1148-1155, database is CAplus and MEDLINE.
New structures of isoxazole-moiety-containing thieno[2,3-d]pyrimidine derivatives I (R1 = Me, Ph; R2 = H, Me; R3 = H, Ph; R4 = H, 4-Me, 4-MeO, etc.) were synthesized for the first time and their in vitro anticancer activity against lung cancer A549, colorectal HCT116 and breast cancer MCF-7 cell lines was preliminarily evaluated using the MTT method. Most of the compounds exhibited good to excellent anticancer activity. In particular, I (R1 = Me; R2, R3 = H; R4 = Br), I (R1, R3 = Ph; R2 = H; R4 = 4-MeO) and I (R1, R3 = Ph; R2 = H; R4 = 4-Br) exhibited a broad spectrum and more potent anticancer activity against A549, HCT116 and MCF-7 cell lines, which can be regarded as the promising anticancer drug-candidates.
Anti-Cancer Agents in Medicinal Chemistry published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C14H10O4S2, Name: 3-(2-Chlorophenyl)-5-isoxazolemethanol.
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