Yang, Xingye published the artcileOptical Control of CRAC Channels Using Photoswitchable Azopyrazoles, Computed Properties of 328-90-5, the publication is Journal of the American Chemical Society (2020), 142(20), 9460-9470, database is CAplus and MEDLINE.
The Ca2+ release-activated Ca2+ (CRAC) channels control many Ca2+-modulated physiol. processes in mammals. Hyperactivating CRAC channels are known to cause several human diseases, including Stormorken syndrome. Here, we show the design of azopyrazole-derived photoswitchable CRAC channel inhibitors (designated piCRACs), which enable optical inhibition of store-operated Ca2+ influx and downstream signaling. Moreover, piCRAC-1 has been applied in vivo to alleviate thrombocytopenia and hemorrhage in a zebrafish model of Stormorken syndrome in a light-dependent manner.
Journal of the American Chemical Society published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C26H45N5O7Si2, Computed Properties of 328-90-5.
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