Vorcakova, Katarina published the artcileSynthesis and characterization of new inhibitors of cholinesterases based on N-phenylcarbamates: In vitro study of inhibitory effect, type of inhibition, lipophilicity and molecular docking, Formula: C12H20O6, the publication is Bioorganic Chemistry (2018), 280-289, database is CAplus and MEDLINE.
Based on current treatment of Alzheimer’s disease, where the carbamate inhibitor Rivastigmine is used, two series of carbamate derivatives were prepared: (i) N-phenylcarbamates with addnl. carbamate group and (ii) N-phenylcarbamates with monosaccharide moiety. All compounds were tested for the inhibitory effect on both of the cholinesterases, elec. eel acetylcholinesterase (eeAChE) and butyrylcholinesterase from equine serum (eqBChE) and the inhibitory activity (expressed as IC50 values) was compared with that of the established drugs Galanthamine and Rivastigmine. The compounds with two carbamate groups revealed higher inhibitory efficiency on both cholinesterases in compared with monosaccharide derived carbamates and with Rivastigmine. The significant decrease of inhibitory efficiency on eqBChE (also for eeAChE but in less manner) was observed after deacetalization of monosaccharide. Moreover, the type of inhibitory mechanism of five chosen compounds was studied. It was found, that compounds with two carbamate groups act presumably via a mixed inhibitory mechanism and the compounds with monosaccharide moiety act as noncompetitive inhibitors. The lipophilicity of tested compounds was determined using partition coefficient Specific positions of the inhibitors in the binding sites of cholinesterases were determined using mol. modeling and the results indicate the importance of phenylcarbamate orientation in the catalytic gorges of both enzymes.
Bioorganic Chemistry published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C8H10S, Formula: C12H20O6.
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