Velu, Sadanandan E. published the artcileTethered Dimer Inhibitors of NAD Synthetase: Parallel Synthesis of an Aryl-Substituted SAR Library, Recommanded Product: 3-Morpholinophenol, the publication is Journal of Combinatorial Chemistry (2005), 7(6), 898-904, database is CAplus and MEDLINE.
The authors previously reported that tethered dimers containing indoles on one end and a permanent pos. charge on the other, using a 6-9 carbon polymethylene tether, provided NAD synthetase inhibitors with impressive antibacterial activities against Gram-positives. Here, the authors report that the Ph ring is a good substitute for indole, and the authors utilize solution-phase parallel synthesis to explore structure-activity relationships for substituents on that ring. General conclusions are that nonpolar substituents are more effective than polar ones and that different positional isomers often have very different enzyme inhibition activities. This latter observation reveals that enzyme activity is sensitive to minor structural changes and suggests that nonspecific detergent actions are not important for the observed effects.
Journal of Combinatorial Chemistry published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C7H6Cl2, Recommanded Product: 3-Morpholinophenol.
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