Ubale, Akash S.’s team published research in Journal of Organic Chemistry in 87 | CAS: 96-20-8

Journal of Organic Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C10H15NO, Name: 2-Aminobutan-1-ol.

Ubale, Akash S. published the artcileTransition-Metal-Free Alkylative Aromatization of Tetralones using Alcohols/Amino Alcohols Toward the Synthesis of Bioactive Naphthol and Benzo[e/g]indole Derivatives, Name: 2-Aminobutan-1-ol, the publication is Journal of Organic Chemistry (2022), 87(12), 8104-8117, database is CAplus and MEDLINE.

Herein, the synthesis of bioactive naphthols I (R1 = H, 6-Br, 6-MeO, 7-MeO; R2 = Ph, 3-MeC6H4, 2-thienyl, etc.) and II or benzindoles III (R3 = Me, Et, PhCH2, etc.) and IV by alkylative aromatization of the corresponding 1- and 2-tetralones with alcs. R2CH2OH or amino alcs. H2NCHR3CH2OH in the presence of NaOH using aerobic oxidative cross-coupling protocol is reported. This is a general and transition-metal-free method, which uses an inexpensive base, does not require inert conditions, and furnishes water and hydrogen peroxide as byproducts. Moreover, this method is compatible with a wide substrate scope and showed exclusive regioselectivity.

Journal of Organic Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C10H15NO, Name: 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts