Tian, Wei published the artcileNovel Anthraquinone Compounds Induce Cancer Cell Death through Paraptosis, Synthetic Route of 622-40-2, the publication is ACS Medicinal Chemistry Letters (2019), 10(5), 732-736, database is CAplus and MEDLINE.
Novel anthraquinone compounds that induce ER stress and paraptosis-like cell death were designed and synthesized. Compound I is the first organic micromol. to kill tumor cells by only paraptosis, and its mechanism of action has been further explored. Paraptosis does not appear to involve either phosphatidylserine translocation associated with apoptosis or cell cycle arrest. The bisbenzyloxy and N-(2-hydroxyethyl)formamide structures may be two critical pharmacophores for paraptosis. Bisbenzyloxy can induce ER stress, and the N-(2-hydroxyethyl)formamide structure can increase the ratio of LC3II/I and cytoplasmic vacuolization and facilitates paraptosis. Some antitumor drugs fail to eradicate malignant cell lines with impaired apoptotic pathways; paraptosis may be a route to kill such cells and provides a new potential strategy for cancer chemotherapy.
ACS Medicinal Chemistry Letters published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C14H14, Synthetic Route of 622-40-2.
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