Serna, Sonia published the artcileConstruction of N-Glycan Microarrays by Using Modular Synthesis and On-Chip Nanoscale Enzymatic Glycosylation, Product Details of C13H19NO3, the main research area is construction glycan microarray modular synthesis chip nanoscale enzymic glycosylation.
An effective chemoenzymic strategy is reported that has allowed the construction, for the first time, of a focused microarray of synthetic N-glycans. Based on modular approaches, a variety of N-glycan core structures have been chem. synthesized and covalently immobilized on a glass surface. The printed structures were then enzymically diversified by the action of three different glycosyltransferases in nanodroplets placed on top of individual spots of the microarray by a printing robot. Conversion was followed by lectin binding specific for the terminal sugars. This enzymic extension of surface-bound ligands in nanodroplets reduces the amount of precious glycosyltransferases needed by seven orders of magnitude relative to reactions carried out in the solution phase. Moreover, only those ligands that have been shown to be substrates to a specific glycosyltransferase can be individually chosen for elongation on the array. The methodol. described here, combining focused modular synthesis and nanoscale on-chip enzymic elongation, could open the way for the much needed rapid construction of large synthetic glycan arrays.
Chemistry – A European Journal published new progress about Affinity. 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, Product Details of C13H19NO3.
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