Ogden, Phillip B. published the artcileReversed phase HPLC with high temperature ethanol/water mobile phases as a green alternative method for estimation of octanol/water partition coefficients, Recommanded Product: n-Octanol, the main research area is high temperature liquid chromatog ethanol water mobile phase; octanol partition coefficient linear solvation energy relationship; Ethanol/water mobile phases; High temperature liquid chromatography; Linear solvation energy relationships; Octanol/water partition coefficient; Snyder-soczewinski equation.
High temperature ethanol/water was explored as a green eluent in the reversed-phase liquid chromatog. approximation of pure water retention (log kw) and subsequent estimation of the octanol/water partition coefficient (log P) via the Collander equation and the Leave-One-Out method. As part of this work, linear solvation energy relationships were employed to compare the log kw extrapolated systems based on high temperature ethanol/water, ambient acetonitrile/water, and ambient methanol/water mobile phases. Based on the comparisons of the three organic modifiers, high temperature ethanol/water mobile phases were observed to provide the best estimation of log P. This conclusion is based on a high log P correlation of 0.968 R2 and a near unity cos θ value of 0.997 between LSER coefficient vectors of ethanol/water estimated log P and octanol/water log P systems. The method employed in this work, further, provided high correlation for the hydrogen-bonding basicity term between the two systems.
Journal of Chromatography A published new progress about Partition. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Recommanded Product: n-Octanol.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts