Murillo-Cremaes, Nerea published the artcileNanostructured silica-based drug delivery vehicles for hydrophobic and moisture sensitive drugs, SDS of cas: 328-90-5, the publication is Journal of Supercritical Fluids (2013), 34-42, database is CAplus.
Facile and robust fabrication methodologies of complex materials with high added value for controlled drug delivery systems are highly sought-after in the pharmaceutical industry. Here, the authors have relied on the use of supercritical fluids for the matrix synthesis as well as for the drug impregnation process. As a model system of a hydrophobic and moisture sensitive active agent, triflusal was impregnated in different aerogel and polymeric matrixes using supercritical CO2. In vitro release profiles of drug carriers consisting of SiO2 aerogels as mesoporous monoliths and as microporous nanospheres loaded with triflusal are reported and compared to a more conventional polymeric system (PMMA). Silica-based matrixes are found to prevent the hydrolization of the active ingredient more efficiently than the polymeric matrix and displayed much faster release kinetics. Moreover, the triflusal is dispersed in a mol. form inside the silica-based materials. Such features are considered of great interest to enhance the bioavailability of low solubility drugs.
Journal of Supercritical Fluids published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, SDS of cas: 328-90-5.
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