Lin, Wenjing published the artcilePrevention effect of Guyuan Fujiu decoction combined with carboprost tromethamine on postpartum hemorrhage caused by uterine inertia in vaginal delivery, Application In Synthesis of 58551-69-2, the publication is Jianyan Yixue Yu Linchuang (2021), 18(16), 2335-2338, 2343, database is CAplus.
Objective To observe the preventive effect of Guyuan Fujiu decoction combined with carboprost tromethamine on postpartum hemorrhage caused by uterine inertia in vaginal delivery. Methods A total of 110 cases of postpartum hemorrhage due to uterine inertia in the hospital from Apr. 2018 to June 2020 were randomly divided into control group and observation group, 55 cases in each group. The control group was given carboprost tromethamine injection after the delivery of the fetus, and the observation group was given Guyuan Fujiu decoction on the basis of the control group. The incidence of postpartum hemorrhage, amount of postpartum hemorrhage, hemostatic time, use of other hemostatic measures, changes of Hb and hematocrit were compared between the two groups. Results The postpartum hemorrhage rate of the observation group (3.64%) was significantly lower than that of the control group (14.55%), the difference was statistically significant (χ2=3.960, P<0.05). Postpartum hemostasis time [(23.56±3.14) min] was significantly shorter than that in the control group [(40.05±5.74) min], the difference was statistically significant (t=18.691, P<0.05). Compared with the control group, the amount of bleeding in the observation group decreased significantly at 30 min, 2 h and 24 h postpartum (t=8.654, 13.495 and 15.496, P<0.05). The application rate of other hemostatic measures in the observation group (7.27%) was significantly lower than that in the control group (21.82%) (χ2=4.681, P<0.05). Compared with the control group, the decrease of maternal Hb and hematocrit in the observation group were significantly reduced (t=22.817, 28.939, P<0.05). Compared with the control group, the serum D-dimer level in the observation group was significantly lower at 2 h postpartum, and the FIB level was significantly higher (t=19.492, 17.256, P<0.05). The level of serum antithrombin-III in the observation group was significantly higher than that in the control group (t=6.090, 10.092, P<0.05). The adverse reaction rate of the observation group (7.27%) was lower than that of the control group (16.36%), but the difference was not statistically significant (χ2=2.181, P>0.05). Conclusion Guyuan Fuguo decoction combined with carboprost tromethamine can be used to prevent uterine hypostasis postpartum hemorrhage, reduce postpartum hemorrhage, improve coagulation function, promote uterine contraction and drug safety.
Jianyan Yixue Yu Linchuang published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Application In Synthesis of 58551-69-2.
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