Li, Xin published the artcileSmall molecule-mediated upregulation of CCR7 ameliorates murine experimental autoimmune encephalomyelitis by accelerating T-cell homing, Formula: C9H21NO3, the publication is International Immunopharmacology (2017), 33-41, database is CAplus and MEDLINE.
Impairing the infiltration of immune cells into the CNS is a promising target for suppressing the development of multiple sclerosis (MS) and its animal model exptl. autoimmune encephalomyelitis (EAE). Here, we found that oral administration of a synthetic small mol. compound Fc24 showed potential preventive effects on the development of EAE, including the reduction in EAE severity and a delay in the onset of the disease. Fc24 facilitated the accumulation of both CD4+ and CD8+ T cells within spleen and lymph nodes, while having no effect on MOG-specific T cell responses. Furthermore, CCR7 expression was upregulated by Fc24 on activated T cells in vivo and in vitro, accompanied by ERK activation in the treated T cells in response to CCL19. These findings demonstrate that small mol.-mediated CCR7 upregulation might ameliorate EAE by facilitating T cell homing into and within lymphoid organs, and that Fc24 may be a potential candidate for modifying the development of EAE.
International Immunopharmacology published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Formula: C9H21NO3.
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