Krotov, A. I. published the artcileActivity of some quaternary salts of β-aryloxyethylaralkylammonium during the infection of mice by Nippostrongylus brasiliensis, Application In Synthesis of 3818-50-6, the publication is Meditsinskaya Parazitologiya i Parazitarnye Bolezni (1968), 37(3), 361-4, database is CAplus.
Some quaternary salts of β-aryloxyethylaralkylammonium were synthesized and tested in Nippostrongylus braziliensis exptl. infection in mice. The anthelmintic drug naphthamone (N-(β-phenoxyethyl)-N,N-dimethyl-N-benzylammonium β-hydroxynaphthoate) served as a standard. Changes in the cation portion of the napthamone mol. by introduction of various substitutes (e.g. CHO, OH) in the phenoxygroup, or substitution of the latter by the naphthoxy group, gave inactive compounds Introduction of naphthyl, imidazolyl, and other groups instead of the benzyl group results in reduction of the activity, whereas the presence of the thenyl group preserved the activity. The most active compound was bephenium salicylate; bephenium α-bromo-β-hydroxynaphthoate was inactive.
Meditsinskaya Parazitologiya i Parazitarnye Bolezni published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Application In Synthesis of 3818-50-6.
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