Feng, Fan’s team published research in Chemical Research in Chinese Universities in 37 | CAS: 438565-33-4

Chemical Research in Chinese Universities published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C10H8ClNO2, Computed Properties of 438565-33-4.

Feng, Fan published the artcileDesign, Ultrasonic-assisted Synthesis and Evaluation In vitro Antimicrobial Activity of Bis-isoxazole Derivatives Bearing Chloro-pyridinyl Group, Computed Properties of 438565-33-4, the publication is Chemical Research in Chinese Universities (2021), 37(3), 668-673, database is CAplus.

An ultrasonic-assisted synthesis of bis-isoxazole derivatives was developed. Eight 3-(6-chloropyridin-3-yl)-5-{[(3-arylisoxazol-5-yl)methoxy]methyl}isoxazoles I [R1 = H, 4-Me, 2-Cl, etc.] were synthesized by 1,3-dipolar cycloaddition reaction between substituted isoxazolyl alkyne compounds and 6-chloro-N-hydroxynicotinimidoyl chloride. The structures of the synthesized compounds were confirmed by HRMS, FTIR, 1H and 13C NMR spectroscopy. Wherein, the antifungal and antibacterial activities of target compounds were tested. The synthesized compounds I [R1 = 2-methoxy, 2-Cl] exhibited better antifungal activity in comparison with the standard drug itraconazole. The min. inhibitory concentrations(MICs) of compound I [R1 = 2-methoxy, 2-Cl] were both 4μg/mL against Candida albicans ATCC 10231.

Chemical Research in Chinese Universities published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C10H8ClNO2, Computed Properties of 438565-33-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts