Dumitrescu, Lidia published the artcileSynthesis and cytotoxic activity of fluorinated analogs of Goniothalamus lactones. Impact of fluorine on oxidative processes, Safety of (E)-4,4,4-Trifluorobut-2-en-1-ol, the publication is European Journal of Medicinal Chemistry (2010), 45(7), 3213-3218, database is CAplus and MEDLINE.
Novel fluorinated analogs of goniothalamin I (R = Ph) and howiinol A II (R = Ph) were prepared from trifluorocrotonate derivatives Trifluoromethyl-goniothalamin (R/S) derivative I (R = CF3) showed a slightly lower activity than 1, while the trifluoromethyl-howiinol A derivative II (R = CF3) exhibited similar activities on several cell lines in the micromolar range. Unlike (R)-goniothalamin and howiinol A, trifluoromethyl parent compounds remained unchanged when submitted to biomimetic oxidative systems.
European Journal of Medicinal Chemistry published new progress about 83706-94-9. 83706-94-9 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is (E)-4,4,4-Trifluorobut-2-en-1-ol, and the molecular formula is C4H5F3O, Safety of (E)-4,4,4-Trifluorobut-2-en-1-ol.
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