Corey, Elizabeth A. published the artcileInhibitory signaling in mammalian olfactory transduction potentially mediated by Gαo, Computed Properties of 111-87-5, the main research area is mammalian olfactory receptor neuron inhibition modulation transduction; Combinatorial coding; Inhibition; Modulation; Olfaction; Olfactory receptor neurons.
Olfactory GPCRs in mammalian olfactory receptor neurons mediate excitation through the Gαs family member Gαolf. Here we tentatively associate a second G protein, Gαo, with inhibitory signaling in mammalian olfactory transduction by first showing that odor evoked phosphoinositide 3-kinase-dependent inhibition of signal transduction is absent in the native ORNs of mice carrying a conditional OMP-Cre based knockout of Gαo. We then identify an OR from native rat ORNs that are activated by octanol through cyclic nucleotide signaling and inhibited by citral in a PI3K-dependent manner. We show that the OR activates cyclic nucleotide signaling and PI3K signaling in a manner that reflects its functionality in native ORNs. Our findings lay the groundwork to explore the interesting possibility that ORs can interact with two different G proteins in a functionally identified, ligand-dependent manner to mediate opponent signaling in mature mammalian ORNs.
Molecular and Cellular Neuroscience published new progress about Animalia. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Computed Properties of 111-87-5.
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