Barth, Marie-Christin published the artcileSynthesis and characterization of thiocarbonato-linked platinum(IV) complexes, Related Products of alcohols-buliding-blocks, the publication is Dalton Transactions (2022), 51(14), 5567-5576, database is CAplus and MEDLINE.
Herein we show the formation of new oxaliplatin-based platinum(IV) complexes by reaction with DSC-activated thiols via thiocarbonate linkage. Three model complexes based on aliphatic and aromatic thiols, as well as one complex with N-acetylcysteine as biol. active thiol were synthesized. This synthetic strategy affords the expansion of biol. active compounds other than those containing carboxylic, amine or hydroxy groups for coupling to the platinum(IV) center. The complexes were characterized by high-resolution mass spectrometry, NMR spectroscopy (1H, 13C, 195Pt) and elemental anal. Their biol. behavior was evaluated against two ovarian carcinoma cell lines and their cisplatin-resistant analogs. Remarkably, the platinum(IV) samples show modest in vitro cytotoxicity against A2780 cells and comparable effects against A2780cis cells. Two complexes in particular demonstrate improved activity against SKOV3cis cells. The reduction experiment of complex 8, investigated by UHPLC-HRMS, provides evidence of interesting platinum-species formed during reaction with ascorbic acid.
Dalton Transactions published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Related Products of alcohols-buliding-blocks.
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