Argemi, Anna published the artcileSpectroscopic and chromatographic characterization of triflusal delivery systems prepared by using supercritical impregnation technologies, Application In Synthesis of 328-90-5, the publication is Journal of Pharmaceutical and Biomedical Analysis (2008), 46(3), 456-462, database is CAplus and MEDLINE.
This study describes the development and evaluation of an anal. method for the characterization of triflusal (2-acetoxy-4-(trifluoromethyl) benzoic acid) dispersed in sustained delivery systems prepared using supercritical fluid impregnation technol. Characterization assays comprised the determination of the percentage of triflusal and its degradation product impregnated in polymeric supports and further monitoring of the releases of the 2 drug components over time in physiol. conditions. Preliminary delivery profiles were monitored spectrophotometrically using a continuous-flow system. In this case, no selective wavelength for discriminating between triflusal and metabolite was found so that measurements at 225 nm provided overall profiles corresponding to the 2 compounds For a more accurate study, a chromatog. method was developed for monitoring the evolution of the concentration of the 2 components independently. Triflusal and metabolite were separated in a C18 column and 25 mM acetic acid/acetate (pH 5.0) + methanol (40/60 volume/volume) mobile phase. Several triflusal-polymer samples were prepared under different exptl. conditions and release features were evaluated. Excellent delivery systems were obtained with poly(methyl)methacrylate beads treated at 40°C and 190 bar for 48 h using supercritical carbon dioxide as a solvent. These samples showed a constant sustained release of drug for several weeks.
Journal of Pharmaceutical and Biomedical Analysis published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Application In Synthesis of 328-90-5.
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