Anagnostou, Athanasius published the artcileErythropoietin has a mitogenic and positive chemotactic effect on endothelial cells, Product Details of C18H20N2O12, the publication is Proceedings of the National Academy of Sciences of the United States of America (1990), 87(15), 5978-82, database is CAplus and MEDLINE.
A dose-dependent proliferative action of human recombinant erythropoietin on human umbilical vein endothelial cells and bovine adrenal capillary endothelial cells was observed Binding studies with radioiodinated recombinant human erythropoietin revealed a large number (≈27,000) of an apparent single class of receptors with an affinity in the 10-9 M range. Linkage of the radiolabeled ligand to its receptor via a bifunctional crosslinking agent allowed identification of an endothelial cell protein of 45 kilodaltons as the principal receptor associated with this mitogenic effect of erythropoietin. Recombinant human erythropoietin also enhanced the migration of endothelial cells.
Proceedings of the National Academy of Sciences of the United States of America published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Product Details of C18H20N2O12.
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