Zolek, Teresa published the artcileDeposition of pentamidine analogues in the human body – spectroscopic and computational approaches, Application In Synthesis of 111-87-5, the main research area is pentamidine analog Pneumocystis jiroveci pneumonia prophylaxis therapy pharmacotherapy; Computational modelling; Drug-likeness; HSA and DNA interaction; Pentamidine analogues; Proton dissociation constants; Spectrofluorometry.
Bis-benzamidines are a diverse group of compounds with high potential in pharmacotherapy, and among them, pentamidine is a drug of great therapeutic significance in Pneumocystis jiroveci pneumonia (PJP) prophylaxis and therapy. Pharmacokinetic properties of these cationic species such as transport, acid/base equilibrium, and interactions with potential target mols. are still of interest, especially for recently designed compounds To broaden our knowledge drug-likeness, human serum albumin binding, and acidity constants (Ka) were exptl. and theor. examined for five pentamidine analogs 1 – 5 with -NH-CO-chain-CO-NH-bridges of increasing length and O, N, and S atoms in the chain. The studied analogs display very marked activity against Pneumocystis carinii without cytotoxicity that inspired us to perform an in silico anal. of their mode of action based on the hypothesis that the small DNA groove of rich in adenine-thymine pairs is their mol. target. These studies allowed us to classify them as very promising lead mols.
European Journal of Pharmaceutical Sciences published new progress about Absorption. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Application In Synthesis of 111-87-5.
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