Vijayasree, P. published the artcileA simple RP-HPLC method for quantitation of carboprost tromethamine in injection dosage form, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Journal of Global Trends in Pharmaceutical Sciences (2014), 5(4), 2012-2016, database is CAplus.
A new simple, precise, accurate and rapid method was developed for determination of Carboprost Tromethamine from its pharmaceutical dosage form. The separation was carried out on a Waters C18 column (Symmetry -C18, 3.5μm, and 4.6×100mm) in isocratic mode with mobile phase comprising acetate buffer pH 3.7 and methanol (30:70, %volume/volume) by using Agilent 1100 series HPLC system with Agilent Chemstation software. The flow rate was 1 mL/min and Ultra-Violet detection was carried out at 200 nm. Every part of determination was performed at ambient column temperature The retention time was 6.827 min for Carboprost Tromethamine. The developed method was validated for parameters like specificity, accuracy, precision, robustness as per International Conference on Harmonization guidelines. Linearity for Carboprost Tromethamine was in the range of 83-249μg/mL and Correlation coefficient was found to be 0.999. The percentage recovery was found to be in the limit of 98.4-99.3 %. Statistical anal. of the results has been carried out revealing high accuracy and good precision. Hence this method can be of use and value for the quality control department of pharmaceutical companies manufacturing these formulations without any interference due its sensitivity, simplicity and selectivity.
Journal of Global Trends in Pharmaceutical Sciences published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C8H5F3N4, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts