Sakai, Toshinori published the artcileHemodynamic effects of the new dihydropyridine derivative, (±)-2-[benzyl(phenyl)amino]ethyl 1,4-dihydro-2,6-dimethyl-5-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)-4-(3-nitrophenyl)-3-pyridinecarboxylate hydrochloride ethanol (NZ-105) in anesthetized dogs, SDS of cas: 111011-76-8, the publication is Oyo Yakuri (1991), 42(1), 43-54, database is CAplus.
The hemodynamic effects of NZ-105 (I) were compared with those of nicardipine in pentobarbital-anesthetized dogs. NZ-105 had a slow onset and prolonged duration of action in decreasing blood pressure. Doses of 10-100 μg/kg i.v. produced a dose-dependent fall in blood pressure but no significant increase in heart rate. The potency of NZ-105 on blood pressure was about half that of nicardipine. However, the duration of action of NZ-105 was longer while the extent of the fall was similar. A small dose of 10 μg/kg of NZ-105 i.v. produced a hypotensive effect, but a large dose of 300 μg/kg i.v. was required to cause prolongation of the P-Q interval in the ECG. In open-chest dogs, NZ-105 (10 and 30 μg/kg i.v.) tended to increase the central venous pressure and transiently increased the left ventricular end-diastolic pressure but produced no significant change in the maximal rate of rise of the left ventricular pressure. NZ-105 (10 and 30 μg/kg i.v.) increased the coronary sinus outflow but caused no significant change in myocardial oxygen consumption. These results suggest that NZ-105 may be a useful agent with a slow onset and long duration of action, vascular selectivity and minimal cardiac effect in the treatment of hypertension.
Oyo Yakuri published new progress about 111011-76-8. 111011-76-8 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is 2-(Benzyl(phenyl)amino)ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate ethanol hydrochloride, and the molecular formula is C36H45ClN3O8P, SDS of cas: 111011-76-8.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts