Rosenkranz, Herbert S.’s team published research in Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis in 230 | CAS: 1139-46-4

Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Application In Synthesis of 1139-46-4.

Rosenkranz, Herbert S. published the artcileStructural basis of the genotoxicity of nitrosatable phenols and derivatives present in smoked food products, Application In Synthesis of 1139-46-4, the publication is Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis (1990), 230(1), 9-27, database is CAplus and MEDLINE.

The CASE (artificial intelligence-based structure-activity anal.) methodol. for studying structure-activity relationships was applied to investigating the basis of the genotoxicity of phenols and derivatives following exposure to nitrous acid. The structural features identified include availability of positions para or ortho to the hydroxyl groups, that one meta position must remain unoccupied and one ortho or para position must be unsubstituted as well. The analyses revealed that genotoxicity is dependent upon the ease of formation of the active phenyldiazonium intermediate and is influenced only secondarily by the nature of the genotoxicant or its ease of entry into the cell. With this data base, CASE predicts the genotoxicity, following nitrosation, of a number of agents, including serotonin, acetaminophen, and of some naturally-occurring pesticides present in edible plants.

Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Application In Synthesis of 1139-46-4.

Referemce:
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