Prosser, Kathleen E. published the artcile19F-Tagged metal binding pharmacophores for NMR screening of metalloenzymes, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(40), 4934-4937, database is CAplus and MEDLINE.
This study demonstrates the screening of a collection of twelve 19F-tagged metal-binding pharmacophores (MBPs) against the Zn(II)-dependent metalloenzyme human carbonic anhydrase II (hCAII) by 19F NMR. The isomorphous replacement of Zn(II) by Co(II) in hCAII produces enhanced sensitivity and reveals the potential of 19F NMR-based techniques for metalloenzyme ligand discovery.
Chemical Communications (Cambridge, United Kingdom) published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid.
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