Pedersen, R. T. published the artcileIdentification of novel metabolites of the xenoestrogen 4-tert-octylphenol in primary rat hepatocytes, COA of Formula: C14H22O2, the publication is Chemico-Biological Interactions (2000), 128(3), 189-209, database is CAplus and MEDLINE.
A number of environmental pollutants, including 4-tert-alkylphenols, can mimic the actions of endogenous steroids and have the potential to disrupt the endocrine function in humans and animals. The biotransformation of a 4-tert-alkylphenol in isolated rat hepatocytes was studied in order to determine the possible fate and activity of these xenoestrogens in higher vertebrates. Hepatocytes were incubated with 30 μM 4-(1′,1′,3′,3′-tetramethylbutyl)[U-14C]phenol (4-tert-octylphenol; t-OP) for up to 60 min. Radiolabeled metabolites were detected by radio-HPLC and the structures determined by gas chromatog.-mass spectrometry (GC-MS) anal. of the conjugated or aglycon products. After a 15 min incubation, over 97% of t-OP was metabolized to a complex mixture of metabolites. The initial metabolites formed were identified as products of hydroxylation of the aromatic ring to form catechols and methylated catechols, as well as glucuronide conjugates of the catechol metabolites or parent phenol. These products were further metabolized by hydroxylation of the alkyl chain followed by glucuronide conjugation of the alkoxy group. The conjugated metabolites of t-OP are unlikely to retain estrogen receptor activity; however t-OP is metabolized by some pathways that are similar to that of estrogen catabolism, namely by ortho-hydroxylation to form catechols, methylation by catechol O-methyltransferases and ring conjugation by uridine diphosphoglucuronosyl transferases. Further investigations are needed to determine whether 4-tert-alkylphenols can alter circulating sex steroid profiles by acting as substrates of enzymes determining estrogen metabolism and excretion.
Chemico-Biological Interactions published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, COA of Formula: C14H22O2.
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