Ndindayino, F. published the artcileDirect compression and molding properties of co-extruded isomalt/drug mixtures, Related Products of alcohols-buliding-blocks, the main research area is direct compression property isomalt drug mixture extrusion.
Isomalt, a disaccharide alc. was co-extruded with paracetamol or hydrochlorothiazide (HCT) in order to improve its tabletting properties. After extrusion, isomalt was transformed into an amorphous form, while paracetamol remained crystalline Hot stage microscopy showed that HCT was amorphous in the isomalt carrier up to a concentration of 1%. Direct compression of mixtures formulated with co-extruded isomalt/paracetamol powders yielded harder tablets compared with phys. mixtures and no powder agglomeration was observed Direct molding of isomalt co-extruded with either paracetamol or HCT was feasible, yielding hard tablets. A fast dissolution rate was seen for both the compressed and the molded tablets (>80% paracetamol and 60% HCT released within 20 min). The compressed tablets showed a dramatic decrease in tensile strength during storage at 85% RH, while the tensile strength of the molded tablets remained above 0.80 MPa after a 6-mo storage at the same conditions. Co-extrusion of isomalt with paracetamol and HCT dramatically improved the tabletting properties of the mixtures (compared with phys. mixtures of drug and isomalt). Direct molding proved to be a suitable technique to produce isomalt-based tablets.
International Journal of Pharmaceutics published new progress about Compression. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Related Products of alcohols-buliding-blocks.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts