Mortazavian, Hamid published the artcileUnderstanding the role of shape and composition of star-shaped polymers and their ability to both bind and prevent bacteria attachment on oral relevant surfaces, Name: Pentaerythritol tetra(3-mercaptopropionate), the main research area is star shaped polymer bind bacteria attachment oral relevant surface; acrylic acid; antibacterial; antifouling; composition; dental; hydrophobicity; hydroxyapatite; oral; polymer; star-shaped.
In this study, we have prepared a series of 4- and 6-arm star-shaped polymers with varying mol. weight and hydrophobicity in order to provide insight into the role and relationship that shape and composition have on the binding and protecting of oral relevant surfaces (hydroxyapatite, HAP) from bacteria colonization. Star-shaped acrylic acid polymers were prepared by free-radical polymerization in the presence of chain transfer agents with thiol groups, and their binding to the HAP surfaces and subsequent bacteria repulsion was measured. We observed that binding was dependent on both polymer shape and hydrophobicity (star vs. linear), but their relative efficacy to reduce oral bacteria attachment from surfaces was dependent on their hydrophobicity only. We further measured the macroscopic effects of these materials to modify the mucin-coated HAP surfaces through contact angle experiments; the degree of angle change was dependent on the relative hydrophobicity of the materials suggesting future in vivo efficacy. The results from this study highlight that star-shaped polymers represent a new material platform for the development of dental applications to control bacterial adhesion which can lead to tooth decay, with various compositional and structural aspects of materials being vital to effectively design oral care products.
Journal of Functional Biomaterials published new progress about Adsorption. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Name: Pentaerythritol tetra(3-mercaptopropionate).
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