Maness, Peter published the artcileSubstituent Effects on Temperature Dependence of Kinetic Isotope Effects in Hydride-Transfer Reactions of NADH/NAD+ Analogues in Solution: Reaction Center Rigidity Is the Key, Synthetic Route of 596-38-3, the publication is Organic Letters (2020), 22(15), 5963-5967, database is CAplus and MEDLINE.
Substituent effects on the temperature dependence of primary kinetic isotope effects, characterized by ÎEa = EaD – EaH, for two series of the title reactions in acetonitrile were studied. The change from ÎEa â?0 for a highly rigid system to ÎEa > 0 for systems with reduced rigidities was observed The rigidities were controlled by the electronic and steric effects. This work replicates the observations in enzymes and opens a new research direction that studies structure-ÎEa relationship.
Organic Letters published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Synthetic Route of 596-38-3.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
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