Liu, Jia published the artcileAphadilactones A-D, four diterpenoid dimers with DGAT inhibitory and antimalarial activities from a Meliaceae plant, Name: (R)-Oxiran-2-ylmethanol, the publication is Journal of Organic Chemistry (2014), 79(2), 599-607, database is CAplus and MEDLINE.
Aphadilactones A-D isolated from Aphanamixis grandifolia (Meliaceae) are 4 diastereoisomers with an unprecedented carbon skeleton. Their challenging structures and absolute configurations were determined by a combination of spectroscopic data, chem. degradation, fragment synthesis, exptl. CD spectra, and ECD calculations The aphadilactones A-D and their oxidative products were tested for DGAT inhibitory activities in vitro. Aphadilactone C with the 5S,11S,5’S,11’S configuration had potent and selective inhibition against diacylglycerol O-acyltransferase-1 (DGAT-1; IC50 = 0.46 μM; selectivity index >217). Thus, aphadilactone C is the strongest natural DGAT-1 inhibitor discovered to date. The aphadilactones A-D also had significant antimalarial activities against Plasmodium falciparum with in vitro IC50 values of 190, 1350, 170, and 120 nM, resp.
Journal of Organic Chemistry published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Name: (R)-Oxiran-2-ylmethanol.
Referemce:
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