Lhotska, Ivona published the artcilePreparation of citrinin-selective molecularly imprinted polymer and its use for on-line solid-phase extraction coupled to liquid chromatography, Quality Control of 86-48-6, the publication is Analytical and Bioanalytical Chemistry (2019), 411(11), 2395-2404, database is CAplus and MEDLINE.
A new selective molecularly imprinted polymer has been prepared and used for extraction in online SPE-HPLC to achieve the selective determination of citrinin. Four different imprinted polymers varying in combinations of components were prepared by bulk polymerization and evaluated in terms of binding capacity and selectivity. Imprinted polymer prepared from a mixture comprising 1-hydoxy-2-naphtoic acid as the template mol., acrylamide as the structural monomer, ethylene dimethacrylate as the cross-linker (in a molar ratio of 1:4:16), and acetonitrile as the porogenic solvent exhibited the best properties. The selectivity of this sorbent was confirmed by comparison with the non-imprinted counterpart prepared using the same polymerization carried out in the absence of template. Imprinted polymer was packed in a 20 × 3 mm i.d. steel cartridge and coupled to the online SPE-HPLC system through a six-port switching valve. The method for determination of citrinin including the online extraction step was then developed and validated. The sample in the form of methanolic extract was loaded, cleaned, and preconcd. in the imprinted SPE cartridge. Subsequent separation of citrinin from residual interferences was achieved using the anal. column Kinetex Biphenyl 100 × 4.6 mm i.d., 5 μm particle size, and fluorescence detection (Ex 335, Em 500 nm). The total anal. time was only 9.50 min. Our fully validated method was also applied to anal. of food supplements based on red yeast rice extracts, the control of which is implemented in European legislation. Only minor yet acceptable contamination was found in tested samples.
Analytical and Bioanalytical Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Quality Control of 86-48-6.
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