Kobayashi, Takashi published the artcileNovel 2-amino-1,4-dihydropyridine calcium antagonists. II. Synthesis and antihypertensive effects of 2-amino-1,4-dihydropyridine derivatives having N,N-dialkylaminoalkoxycarbonyl groups at 3- and/or 5-position, COA of Formula: C10H15NO, the publication is Chemical & Pharmaceutical Bulletin (1995), 43(5), 797-817, database is CAplus and MEDLINE.
Novel 2-amino-1,4-dihydropyridine derivatives, e.g. I (R1 and R2 = N,N-dialkylaminoalkyl, 1-benzylpiperidin-3-yl, 1-benzhydrylazetidin-3-yl, Me, iso-Pr, R3 = 3-NO2C6H4, 2,3-Cl2C6H3, 3-CF3C6H4, R4= NH2, CH3) were synthesized and their antihypertensive effects were evaluated in spontaneously hypertensive rats. Remarkably prolonged duration of antihypertensive action was observed when a tertiary amino group was introduced into either the 3- and 5-ester side-chain of the 1,4-dihydropyridine ring. In particular, the compounds containing cyclic amino moieties at the 3-position showed greater potency than those with acyclic amino moieties. Chem. modification studies indicated that the two ester side-chains of 1,4-dihydropyridine at the 3- and 5-position might function in a different manner in relation to the antihypertensive activities. CS-905, I (R1 = 1-benzhydrylazetidin-3-yl, R2 = iso-Pr, R3 = 3-NO2C6H4, R4 = NH2) exhibited potent and long-lasting antihypertensive effects with gradual onset of action, and is a promising candidate as an antihypertensive drug.
Chemical & Pharmaceutical Bulletin published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, COA of Formula: C10H15NO.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts