Kang, Seok Hee published the artcilePLGA Microsphere Addition to 1-Hydroxy-2-naphthoic Acid Enhances the Sustained Release of Escitalopram, Related Products of alcohols-buliding-blocks, the publication is Bulletin of the Korean Chemical Society (2019), 40(8), 791-795, database is CAplus.
Escitalopram (ET), a selective serotonin reuptake inhibitor, has been utilized for the treatment of depression and anxiety.However, ET has serious side effects such as nausea, leading to an increased therapeutic dose, needing multiple administrations.Therefore, to overcome these issues, we developed ET encapsulated poly (d,l-lactic-co-glycolic acid) (PLGA) microspheres (PLGA-MS) as a sustained release carrier to maintain therapeutic efficacy.The mean particle size of the PLGA-MSs was measured by microscopy.Loading efficiency was measured by high performance liquid chromatog. (HPLC). Morphologies were determined by microscopy and SEM (SEM).Differential scanning calorimetry (DSC) was used for thermal anal. and glass transition temperature determinationMean particle size of the ET-loaded PLGA-MSs was 129 ± 14μm, loading efficiency was 36.8 ± 9.1%, and encapsulation efficiency was up to 70.6 ± 6.8%.Loading efficiency and encapsulation efficiency were increased by the addition of 1-hydroxy-2-naphthoic acid (HNA).ET was released from PLGA-MS for 4 wk, which was longer than ET release from PLGA-MS without the addition of HNA.Taken together, we demonstrate the optimum condition for sustained release of ET from PLGA-MS with the addition of HNA, and that this approach may be useful for depression therapy.
Bulletin of the Korean Chemical Society published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Related Products of alcohols-buliding-blocks.
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