Joshi, Suraj R. published the artcileConstruction, analysis and validation of co-expression network to understand stress adaptation in Deinococcus radiodurans R1, Related Products of alcohols-buliding-blocks, the publication is PLoS One (2020), 15(6), e0234721, database is CAplus and MEDLINE.
In the current study, we have performed system-level anal. for Deinococcus radiodurans R1 by constructing a gene co-expression network based on several microarray datasets available in the public domain. This condition-independent network was constructed by Weighted Gene Co-expression Network Anal. (WGCNA) with 61 microarray samples from 9 different exptl. conditions. We identified 13 co-expressed modules, of which, 11 showed functional enrichments of one or more pathway/s or biol. process. Comparative anal. of differentially expressed genes and proteins from radiation and desiccation stress studies with our co-expressed modules revealed the association of cyan with radiation response. We obtained 7 TFs for radiation and desiccation responsive modules. The expressions of 3 TFs were validated in response to gamma radiation using qRT-PCR. Along with the TFs, selected close neighbor genes of two important TFs, viz., DR_0997 (CRP) and DR_2287 (AsnC family transcriptional regulator) in the darkgreen module were also validated. In our network, among 13 hub genes associated with 13 modules, the functionality of 5 hub genes which are annotated as hypothetical proteins (hypothetical hub genes) in D. radiodurans genome has been revealed. Overall the study provided a better insight of pathways and regulators associated with relevant DNA damaging stress response in D. radiodurans.
PLoS One published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Related Products of alcohols-buliding-blocks.
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