Isaacs, W. B. published the artcileAssociation of titin and myosin heavy chain in developing skeletal muscle, Category: alcohols-buliding-blocks, the publication is Proceedings of the National Academy of Sciences of the United States of America (1992), 89(16), 7496-500, database is CAplus and MEDLINE.
To understand mol. interactions that organize developing myofibrils, the biosynthesis and interaction of titin and myosin heavy chain in cultures of developing chicken leg myoblasts were examined Use of pulse-labeling, immunoprecipitation, and a reversible crosslinking procedure demonstrates that within minutes of synthesis, titin and myosin heavy chain can be chem. crosslinked into very large, detergent-resistant complexes retaining many features of intact myotubes. These complexes, predominantly of titin and myosin, occur very early in myofibrillogenesis as well as later. Apparently, synthesis and assembly of titin and myosin are temporally and spatially coordinated in nascent myofibrils, and titin mols. may help to organize sarcomere formation.
Proceedings of the National Academy of Sciences of the United States of America published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Category: alcohols-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
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