Huber, Verena published the artcileUncovering the curcumin solubilization ability of selected natural deep eutectic solvents based on quaternary ammonium compounds, Recommanded Product: 2-Hydroxy-2-phenylacetic acid, the publication is Journal of Molecular Liquids (2022), 119661, database is CAplus.
The solubility of curcumin in ethanolic solutions can be increased twentyfold through the addition of natural deep eutectic solvents (NADES). Instead of only screening nine different NADES based on choline chloride, betaine, and carnitine mixed with lactic, levulinic, and pyruvic acid in terms of their solving ability, they were investigated regarding the mechanism of solvation as well. The curcumin solubility enhancement was assessed via UV/Vis measurements, while the investigation of the intermol. effects was performed theor. by COSMO-RS predictions of the chem. potential and exptl. via 1H and NOESY NMR measurements. The addition of the quaternary ammonium compounds to ethanol resulted in a solubility increase regardless of addnl. functionalities, which was not the case for the acids, where functionalities showed a significant influence. A solubility synergy in the levulinic acid NADES was reached, which could be explained through the combination of COSMO-RS and NMR experiments, yielding indications that an interplay of non-specific and directed intermol. interactions was the responsible driving force for an efficient solubility enhancement of curcumin. Thus, the NADES based on levulinic acid achieved the best results.
Journal of Molecular Liquids published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Recommanded Product: 2-Hydroxy-2-phenylacetic acid.
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