Hu, Yiping published the artcileDesign, Synthesis, Molecular Docking Studies of Deferasirox Derivatives of 1,2,4-Triazole as Potential Antimicrobial Agents, Formula: C8H5F3O3, the publication is ChemistrySelect (2021), 6(45), 12914-12920, database is CAplus.
A series of deferasirox derivatives of 1,2,4-triazole I (R1 = H, CF3; R2 = R3 = H, CF3, COOH, COOMe, COOEt) were designed and synthesized by the ring-opening rearrangement reaction of Ph hydrazine or its substituents and imines, some compounds are previously unknown. The antibacterial activities of all compounds against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Candida albicans and Aspergillus niger were exptl. evaluated. Most of them exhibited potential antimicrobial activity and promising antifungal activity. Especially, I (R1 = CF3; R2 = COOEt; R3 = H) and I (R1 = CF3; R2 = H; R3 = COOEt) showed the best antimicrobial activity (MIC90 = 0.125-2.0μg/mL) against Staphylococcus aureus, Staphylococcus epidermidis and Escherichia coli, while compounds I (R1 = R2 = H; R3 = COOMe), I (R1 = CF3; R2 = COOMe; R3 = H) showed excellent antifungal activity (MIC90 = 0.5-2.0μg/mL). The mol. docking anal. further revealed that all the synthesized derivatives have shown potential binding affinities.
ChemistrySelect published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Formula: C8H5F3O3.
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