Grabosch, Carsten published the artcileA dual Click’ strategy for the fabrication of bioselective, glycosylated self-assembled monolayers as glycocalyx models, Quality Control of 96345-79-8, the publication is Organic & Biomolecular Chemistry (2013), 11(24), 4006-4015, database is CAplus and MEDLINE.
Solid surfaces decorated with specific saccharide patterns can serve as a model for the chem. and structurally highly complex glycocalyx of eukaryotic cells. Here we present an approach based on self-assembled monolayers on gold, which are built up in a three-step manner to provide a solid basis, a biorepulsive oligoethylene glycol part, and a specific glycoside terminus, e.g. I, in a modular way. Of the different reaction sequences, the one with two consecutive click reactions’ (the copper(I)-catalyzed 1,3-dipolar cycloaddition of alkynes with azides and the thiourea-bridging of isothiocyanates with amines) directly on SAM’ results in the densest layers, as demonstrated by IR absorption reflection spectroscopy and ellipsometry. As a real life’ test, the surfaces obtained this way were used for bacterial adhesion experiments Here the biorepulsivity of the middle part of the SAMs as well as specific binding to the carbohydrate termini could be clearly demonstrated.
Organic & Biomolecular Chemistry published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Quality Control of 96345-79-8.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts