Gential, Geoffroy P. P. published the artcileSynthesis and evaluation of fluorescent Pam3Cys peptide conjugates, HPLC of Formula: 57044-25-4, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(15), 3641-3645, database is CAplus and MEDLINE.
Chirally pure R- and S-epimers of TLR2 ligand Pam3CysSK4 were prepared and sep. conjugated to an OVA model epitope, in which lysine was replaced by azidonorleucine. The azide function in the conjugate permitted labeling with different fluorophores by use of strain-promoted 3+2 cycloaddition The R-epimer of the labeled conjugates induced TLR2-dependent DC maturation, while S-epimer proved to be inactive. Combining the lipophilicity of Pam3CysSK4 ligand with fluorophores influenced the solubility of the resulting conjugates in an unpredictable way and only the conjugates labeled with Cy-5 were suitable for confocal fluorescence microscopy experiments It was shown that both epimers of the Cy-5 labeled lipopeptides were internalized equally well, indicating TLR2-independent cellular uptake. The presented results demonstrate the usefulness of strain-promoted azide-alkyne cycloaddition in the labeling of highly lipophilic lipopeptides without disturbing the in vitro activity of these conjugates with respect to activation of TLR-2.
Bioorganic & Medicinal Chemistry Letters published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, HPLC of Formula: 57044-25-4.
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