Dambatta, Mubarak B. published the artcileTransition metal free α-C-alkylation of ketones using secondary alcohols, Application In Synthesis of 584-02-1, the main research area is aryl ketone preparation; ketone secondary alc alkylation.
A base-mediated α-C-alkylation of aryl Me ketones with secondary alcs. was developed for the synthesis of aryl ketones ArC(O)CH2CH(R1)(R2) [R1 = Me, Et; R2 = Me, Et, Ph, etc.; R1R2 = (CH2)4, (CH2)5, (CH2)6, etc.; Ar = 2,4,6-(Me)3C6H2, 2,3,5,6-(Me)4C6H, 2,3,4,5,6-pentamethylphenyl, etc.]. This transition metal free approach employed KOt-Bu as the base and exhibited a broad scope, allowing a range of commodity aliphatic secondary alcs. Aryl Me ketones underwent selective mono-α-C-alkylation in high isolated yields (23 examples, 65% average yield).
Tetrahedron published new progress about Alkylation. 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Application In Synthesis of 584-02-1.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts