Chen, Shi-yun published the artcileSynthesis of related substances for ambroxol hydrochloride glucose injection, Category: alcohols-buliding-blocks, the publication is Huaxue Shiji (2019), 41(10), 1098-1100, database is CAplus.
To perform the quality control of ambroxol hydrochloride glucose injection, related substance 4-(6, 8-dibromo-3, 4-dihydroquinazoline-3-yl)-cyclohexanol was prepared 4-(6, 8-Dibromo-3, 4-dihydroquinazoline-3-yl)-cyclohexanol was synthesized from ambroxol hydrochloride and formaldehyde by cyclization and oxidation reactions. The structure of 4-(6, 8-dibromo-3, 4-dihydroquinazoline-3-yl)-cyclohexanol was confirmed by IR, 1HNMR, 13CNMR and ESI-MS. The synthetic route designed in this work is simple and the post-processing is convenient, can be used to provide the material foundation for ambroxol hydrochloride related substances 4-(6,8-dibromo-3,4-dihydroquinazoline-3-yl)-cyclohexanol reference substance preparation
Huaxue Shiji published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Category: alcohols-buliding-blocks.
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