Chen, Hui-xia published the artcileClinic efficacy of carboprost tromethamine in preventing vaginal delivery postpartum hemorrhage in subsequent pregnancy after cesarean parturition, Formula: C25H47NO8, the publication is Zhongguo Linchuang Yanjiu (2013), 26(6), 565-566, database is CAplus.
Objective To evaluate efficacy and safety of carboprost tromethamine (Hemabate) in preventing vaginal delivery postpartum hemorrhage in subsequent pregnancy after cesarean parturition. Methods: 96 cases of vaginal delivery subsequently pregnant women after cesarean parturition were randomly divided into observation group of 46 cases and control group of 50 cases, and the observation group was given oxytocin 20U by i.v. infusion after delivery and Hemabate 250μg by deep i.m. injection in hip, while the control group was given oxytocin 20U by i.v. infusion after delivery. Postpartum hemorrhage between the groups and postpartum hemorrhage amount in 2h were compared. Results: Observation group had one case of postpartum hemorrhage (2.17%), and control group had 6 cases of postpartum hemorrhage in (12.00%), and the two groups showed no significant difference (P > 0.05 ). Observation group had decrease in average 2h postpartum hemorrhage amount than the control group (207.34 ± 78.88) vs (263.64 ± 87.49) ml, and the difference was statistically significant P < 0.05. Conclusions: Hemabate can be used for preventing vaginal delivery postpartum hemorrhage in subsequent pregnancy after cesarean parturition with high safety, to some extent, can reduce the incidence of postpartum hemorrhage.
Zhongguo Linchuang Yanjiu published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Formula: C25H47NO8.
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