Cai, Zhongyu published the artcileResponsive Photonic Crystal Carbohydrate Hydrogel Sensor Materials for Selective and Sensitive Lectin Protein Detection, HPLC of Formula: 2595-07-5, the main research area is photonic crystal carbohydrate hydrogel sensor detection lectin; biosensors; carbohydrate hydrogels; copolymerization; lectin proteins detection; photonic crystals.
Lectin proteins, such as the highly toxic lectin protein, ricin, and the immunochem. important lectin, jacalin, play significant roles in many biol. functions. It is highly desirable to develop a simple but efficient method to selectively detect lectin proteins. Here the authors report the development of carbohydrate containing responsive hydrogel sensing materials for the selective detection of lectin proteins. The copolymerization of a vinyl linked carbohydrate monomer with acrylamide and acrylic acid forms a carbohydrate hydrogel that shows specific “”multivalent”” binding to lectin proteins. The resulting carbohydrate hydrogels are attached to 2-D photonic crystals (PCs) that brightly diffract visible light. This diffraction provides an optical readout that sensitively monitors the hydrogel volume The authors use lactose, galactose, and mannose containing hydrogels to fabricate a series of 2-D PC sensors that show strong selective binding to the lectin proteins ricin, jacalin, and Con A. This binding causes a carbohydrate hydrogel shrinkage which significantly shifts the diffraction wavelength. The resulting 2-D PC sensors can selectively detect the lectin proteins ricin, jacalin, and Con A. These unoptimized 2-D PC hydrogel sensors show a limit of detection (LoD) of 7.5 × 10-8 M for ricin, a LoD of 2.3 × 10-7 M for jacalin, and a LoD of 3.8 × 10-8 M for Con A, resp. This sensor fabrication approach may enable numerous sensors for the selective detection of numerous lectin proteins.
ACS Sensors published new progress about Biosensors. 2595-07-5 belongs to class alcohols-buliding-blocks, name is (2R,3R,4S,5R,6R)-2-(Allyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C9H16O6, HPLC of Formula: 2595-07-5.
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