Boehme, Thomas M. published the artcileStructure-Activity Relationships of Dimethindene Derivatives as New M2-Selective Muscarinic Receptor Antagonists, Quality Control of 101-98-4, the publication is Journal of Medicinal Chemistry (2003), 46(5), 856-867, database is CAplus and MEDLINE.
2,3-Disubstituted indenes, such as I [R = (Me2CH)2N, (FCH2CH2)MeN; n = 2], analogs of the widely used histamine H1 receptor antagonist dimethindene, are prepared as potential M2-selective muscarinic receptor antagonists. (-)-I [R = (Me2CH)2N; n = 2] has comparable affinity for M2 receptors to (S)-dimethindene with 5-275-fold selectivities for the M2 muscarinic receptor over other muscarinic receptor subtypes and over histamine H1 receptors. I [R = (FCH2CH2)MeN; n = 2] also has high affinity for the muscarinic M2 receptor and is selective for the M2 receptor over other muscarinic receptors but possesses high affinity for histamine H1 receptors. I (R = Me2N; n = 1) has the highest affinity of the tested indenes for M2 muscarinic receptors but low selectivity for M2 muscarinic receptors over other muscarinic receptor subtypes.
Journal of Medicinal Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Quality Control of 101-98-4.
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