Bautista-Aguilera, Oscar M. published the artcileAcetylcholinesterase inhibition of diversely functionalized quinolinones for alzheimer’s disease therapy, Synthetic Route of 622-40-2, the publication is International Journal of Molecular Sciences (2020), 21(11), 3913, database is CAplus and MEDLINE.
The synthesis and cholinesterase (ChE)/monoamine oxidase (MAO) inhibition of quinolinones I [R = 2-diethylaminoethyl, 1-methyl-4-piperidyl, 3-morpholinopropyl, etc.] and dihydroquinolinones II [R1 = 1-methyl-4-piperidyl, 2-morpholinoethyl, 2-(4-isopropylpiperazin-1-yl)ethyl, etc.] designed as potential multitarget small mols. (MSM) for alzheimer’s disease therapy was reported.. None of them showed significant human recombinant MAO inhibition, but compounds I [R = 4-(4-isopropylpiperazin-1-yl)butyl, 5-(4-isopropylpiperazin-1-yl)pentyl] and compound II [R1 = 4-(4-isopropylpiperazin-1-yl)butyl] displayed promising human recombinant acetylcholinesterase (hrAChE) and butyrylcholinesterase (hrBuChE) inhibition. In particular, compound I [R = 4-(4-isopropylpiperazin-1-yl)butyl] was found to be a potent and quite selective non-competitive inhibitor of hrAChE (IC50 = 0.29μM), with Ki value in nanomolar range (79 nM). Pertinent docking anal. confirmed this result, suggesting that this ligand was an interesting hit for further investigation.
International Journal of Molecular Sciences published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Synthetic Route of 622-40-2.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts