Baell, Jonathan B. published the artcileNew Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays, Related Products of alcohols-buliding-blocks, the publication is Journal of Medicinal Chemistry (2010), 53(7), 2719-2740, database is CAplus and MEDLINE.
This report describes a number of substructural features which can help to identify compounds that appear as frequent hitters (promiscuous compounds) in many biochem. high throughput screens. The compounds identified by such substructural features are not recognized by filters commonly used to identify reactive compounds Even though these substructural features were identified using only one assay detection technol., such compounds have been reported to be active from many different assays. In fact, these compounds are increasingly prevalent in the literature as potential starting points for further exploration, whereas they may not be.
Journal of Medicinal Chemistry published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Related Products of alcohols-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
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