Li, Xiuru published the artcileMultifunctional Surface Modification of Gold-Stabilized Nanoparticles by Bioorthogonal Reactions, Recommanded Product: (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, the publication is Journal of the American Chemical Society (2011), 133(29), 11147-11153, database is CAplus and MEDLINE.
Nanocarriers that combine multiple properties in an all-in-one system hold great promise for drug delivery. The absence of technol. to assemble highly functionalized devices has, however, hindered progress in nanomedicine. To address this deficiency, the authors have chem. synthesized poly(ethylene oxide)-β-poly(ε-caprolactone) (PEO-b-PCL) block polymers modified at the apolar PCL terminus with thioctic acid and at the polar PEO terminus with an acyl hydrazide, amine, or azide moiety. The resulting block polymers were employed to prepare nanoparticles that have a gold core, an apolar polyester layer for drug loading, a polar PEO corona to provide biocompatibility, and three different types of surface reactive groups for surface functionalization. The acyl hydrazide, amine, or azide moieties of the resulting nanoparticles could be reacted with high efficiencies with modules having a ketone, isocyanate, or active ester and alkyne function, resp. To demonstrate proof of principle of the potential of multisurface functionalization, nanoparticles that have various combinations of an oligo-arginine peptide were prepared to facilitate cellular uptake, a histidine-rich peptide to escape from lysosomes, and an Alexa Fluor 488 tag for imaging purposes. It has been shown that uptake and subcellular localization of the nanoparticles can be controlled by multisurface modification. It is to be expected that the modular synthetic methodol. provides unique opportunities to establish optimal configurations of nanocarriers for disease-specific drug delivery.
Journal of the American Chemical Society published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Recommanded Product: (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol.
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