Li, Jie published the artcileOptimum target plasma concentration of propofol in preventing adverse effects of carboprost tromethamine in patients undergoing caesarean section, Safety of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Zhonghua Mazuixue Zazhi (2016), 36(3), 321-324, database is CAplus.
Objective To investigate the optimum target plasma concentration of propofol in preventing the adverse effects of carboprost tromethamine in the patients undergoing caesarean section. Methods One hundred and twenty-eight nulliparous parturients who were at full term with a singleton fetus, of American Society of Anesthesiologists phys. status I or II, aged 24-37 yr, weighing 54-78 kg, scheduled for elective caesarean section under combined spinal-epidural anesthesia, were randomly divided into 4 groups (n = 32 each) using a random number table: control group (group C) and different concentrations of propofol groups (P1-3 groups). Carboprost tromethamine 250 μg was injected into the body of the uterus, and propofol with the target plasma concentrations of 0.8, 1.2 and 1.6 μg/mL was simultaneously given by target-controlled infusion in P1, P2 and P3 groups, resp., and normal saline was infused at a rate of 0.5 mL·kg-1·h-1 in group C. The occurrence of cardiovascular events was recorded from the end of carboprost tromethamine administration until the end of surgery. The related adverse effects after carboprost tromethamine administration and Ramsay sedation score at 15 mm after carboprost tromethamine administration were recorded, and satisfactory sedation was defined as Ramsay sedation score of 2. The occurrence of complications associated with combined spinal-epidural anesthesia was recorded during the postoperative follow-up. Results Compared with group C, the incidence of carboprost tromethamine-related adverse effects was significantly decreased in P2 and P3 groups, the rate of satisfactory sedation was significantly increased in P1 and P2 groups, the incidence of hypotension and tachycardia was significantly decreased in group P1 (P<0.05), and no significant change was found in the incidence of carboprost tromethamine-related adverse effects in group P1 and in the rate of satisfactory sedation in group P3 (P>0.05). Compared with group P1, the incidence of carboprost tromethamine-related adverse effects was significantly decreased in P2 and P3 groups, the rate of satisfactory sedation was significantly increased in group P2, and the rate of satisfactory sedation was significantly decreased in group P3 (P<0.05). Compared with group P2, the rate of satisfactory sedation was significantly decreased (P<0.05), and no significant change was found in the incidence of carboprost tromethamine-related adverse effects in group P3 (P>0.05). No cardiovascular events were found in group P2, and the incidence of hypotension was 9% in group P3. Conclusion The optimum target plasma concentration of propofol in preventing the adverse effects of carboprost tromethamine is 1.2 μg/mL in the patients undergoing caesarean section.
Zhonghua Mazuixue Zazhi published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Safety of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.
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